发给老马备查:
$ ~" f" i+ M. M/ L3 N滴水察海(69304838) 15:23:23* E+ H1 X0 z0 n" f
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱( {# S3 i* T$ X9 ~/ _
吉非替尼和S-1连用的依据
6 h! V, G" h2 q5 x" V5 [: F' PGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
$ L# s8 n) {) D% E! `是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
w- V7 v. p. N& V- n* z3 I+ }这样是不是推理出,耐药后,可以用S-1和培美了?
- }/ H* X1 f3 D: }- ? F9 ^结论:! D; `7 s4 D0 @3 d1 @, }+ d, Q
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |